Identification and Phenotype of MAIT Cells in Cattle and Their Response to Bacterial Infections

MD Edmans; TK Connelley; S Jayaraman; C Vrettou; M Vordermeier; JYW Mak; L Liu; DP Fairlie; EA Maze; T Chrun; P Klenerman; SBG Eckle; E Tchilian; L Benedictus

Journal article

Identification and Phenotype of MAIT Cells in Cattle and Their Response to Bacterial Infections

MD Edmans, TK Connelley, S Jayaraman, C Vrettou, M Vordermeier, JYW Mak, L Liu, DP Fairlie, EA Maze, T Chrun, P Klenerman, SBG Eckle, E Tchilian, L Benedictus

Frontiers in Immunology | FRONTIERS MEDIA SA | Published : 2021

DOI: 10.3389/fimmu.2021.627173

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Abstract

Mucosal-associated invariant T (MAIT) cells are a population of innate-like T cells that utilize a semi-invariant T cell receptor (TCR) α chain and are restricted by the highly conserved antigen presenting molecule MR1. MR1 presents microbial riboflavin biosynthesis derived metabolites produced by bacteria and fungi. Consistent with their ability to sense ligands derived from bacterial sources, MAIT cells have been associated with the immune response to a variety of bacterial infections, such as Mycobacterium spp., Salmonella spp. and Escherichia coli. To date, MAIT cells have been studied in humans, non-human primates and mice. However, they have only been putatively identified in cattle by..

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Sidonia Eckle Author

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Awarded by National Institute for Health Research

Funding Acknowledgements

This work was funded by the UK Biotechnology and Biological Sciences Research Council (BBSRC, Grant numbers BB N004647/1, BBS/E/I/00007031, BBS/E/I/00007038 and BBS/E/I/00007039) and the bovine tuberculosis research budget held and administered centrally by the UK Department for Environment, Food and Rural affairs on behalf of England, Scotland and Wales (Project Code SE3299). Work performed at the University of Oxford was supported by the Wellcome Trust (WT109965MA), NIHR Senior Fellowship (PK). Work at the Roslin Institute is supported by Strategic Program Grants from the BBSRC. SE was supported by an Australian Research Council DECRA fellowship (DE170100407) and an Australian National Health and Medical Research Council Project grant (APP1157388). DF is supported by a Senior Principal Research Fellowship (1117017) from the Australian Research Council (CE140100011) and National Health and Medical Research Council of Australia (NHMRC).